As part of the GE Healthcare BioProcess™ media platform, Capto ImpRes ion exchangers are manufactured under validated production methods, backed up with Regulatory Support Files, and have Secure Supply routines in place. “Capto ImpRes media have been designed to meet the throughput and high resolution needs of intermediate purification and polishing.”Ĭapto ImpRes media are available in several convenient formats, including Predictor™ 96-well filter plates and prepacked HiTrap™ and HiScreen™ columns to support all stages of biopharmaceutical development and manufacture. Get All The Latest News Help & Support Center English English Change Country 0. 09-928-117 434. Fisher Scientific - Cytiva HiTrap Capto PlasmidSelect for gene therapy, DNA vaccine applications Shop Cytiva HiTrap Capto PlasmidSelect at. “The extension of the Capto platform with Capto ImpRes ion exchangers demonstrates our commitment to supporting biopharmaceutical manufacturers with the most modern tools to improve their processes in terms of throughput, productivity, and economy,” said Dr Nigel Darby, Vice President, Biotechnologies, GE Healthcare. Cytiva HiTrap Capto PlasmidSelect For the purification of supercoiled DNA to high quality for gene therapy and DNA vaccine applications Manufacturer: Cytiva 17549911 View more versions of this product Catalog No. The first Capto ImpRes products to be launched are Capto SP ImpRes and Capto Q ImpRes, strong cation and strong anion exchangers, respectively, that enable high throughput, high resolution polishing, and flexibility in process design.Ĭapto ImpRes media are based on a rigid high-flow agarose matrix that allows the use of high flow rates and higher bed heights, providing biopharmaceutical manufacturers with the possibility to reduce cycle times and maintain or reduce column equipment footprint, thus contributing to driving improvements in process economics. Stable in up to 1 M NaOH, 40% Isopropanol, up to 1 M acetic acid, and up to 70% ethanol.Ģ0% ethanol at temperatures between 4☌ and 30☌.GE Healthcare has extended its Capto™ platform to include Capto ImpRes ion exchange chromatography media for late-stage purification of a wide range of biomolecules. Hydrophilic properties of base matrix prevent non-specific binding.īioProcess resin supported for industrial applications.Ĭonvenient small-scale purification, process development, and scale-up using prepacked HiTrap columns.
Higher throughput for improved productivity and process economy. High-flow purification of supercoiled DNA from research scale to cGMP production.įlexible process design due to a large operational window of flow velocities and bed heights. Capto PlasmidSelect is available in bulk as well as in formats suitable for process development. The possibility to run at higher flow rates and bed heights increases flexibility in process design and allows for an increased productivity. Compared with its predecessor PlasmidSelect Xtra resin, Capto PlasmidSelect is based on a more rigid base matrix, delivering excellent pressure-flow properties to plasmid production. The resin is designed for purification of supercoiled DNA to high quality for gene therapy and DNA vaccine applications. Capto PlasmidSelect is a chromatography resin that allows supercoiled covalently closed circular forms of plasmid DNA to be separated from open circular forms.Ĭapto PlasmidSelect is a thiophilic aromatic adsorption chromatography resin with a selectivity that allows supercoiled covalently closed circular forms of plasmid DNA to be separated from open circular forms.
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